Immune Diseases Associated with TREX1 and STING Dysfunction
نویسندگان
چکیده
منابع مشابه
Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing.
Immune sensing of DNA is critical for antiviral immunity but can also trigger autoimmune diseases such as lupus erythematosus (LE). Here we have provided evidence for the involvement of a damage-associated DNA modification in the detection of cytosolic DNA. The oxidized base 8-hydroxyguanosine (8-OHG), a marker of oxidative damage in DNA, potentiated cytosolic immune recognition by decreasing i...
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متن کاملRemoving the TREX1 safety net: oxidized DNA overcomes immune silencing by exonuclease TREX1.
If DNA accumulates in the cytosol, it activates innate immunity via recently described DNA sensors. In this issue of Immunity, Gehrke et al. (2013) show that oxidized DNA is resistant to degradation by TREX1 and thus has heightened immunostimulatory capacity.
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ژورنال
عنوان ژورنال: Journal of Interferon & Cytokine Research
سال: 2017
ISSN: 1079-9907,1557-7465
DOI: 10.1089/jir.2016.0086